This article exposes the development of a device to acquire the potential differences in 1 the epithelial surface of the female breast, using an array of 24 electrodes distributed on the surface 2 of the breast, a signal acquisition board capable to take a reading range of 31.25mV to 1.024V to 3 potential differences in the epithelial surface of the breast and a graphical user interface developed 4 in Matlab®; with what we were able to get a platform to carry out more research into the mode of epithelial potential differences. The device was evaluated with 4 healthy Mexican women who were subject to a prior ultrasound exam or mammography. As a result, of the medical trial, we found different factors that can affect accurate measurement of the breast surface and obtained information about the various stages that contains a device measuring epithelial potential differences found in this region of the human body